![\"\"](\"http:\/\/www.crossref.com.cn\/news\/wp-content\/uploads\/2018\/03\/2018030409495261-1.jpg\")
<\/a><\/p>\n<\/p>\n
\u6587\u7ae0\u88abLeukemia(10\u5206)\uff0cOncogene(6-7\u5206)\uff0cBritish Journal of Haematology (5\u5206),<\/p>\n
Experimental Hematology(2.436\u5206)\u76f4\u63a5\u62d2\u6389\u4e4b\u540e\uff0c\u5c0f\u8001\u677f\u653e\u5f03\u4e86\uff0c\u8ba9\u54b1\u81ea\u5df1\u6295\u3002\u5927\u8001\u677f\u8fd8\u662f\u76f8\u4fe1\u53ef\u4ee5\u53d1\u5728\u4e00\u4e2a\u8fd8\u53ef\u4ee5\u7684\u6742\u5fd7\uff0c\u5efa\u8baeJournal of<\/p>\n
Pathology\u3002\u54b1\u6362\u4e86\u4e00\u4e2a\u81ea\u5df1\u5199\u7684\u7248\u672c\uff0c\u6539\u4e86\u4e00\u4e0b\uff0c\u6295\u4e86\uff0c17\u5e747\u6708\u5e95\u5927\u4fee\uff0c\u518d\u6b21\u5c0f\u4fee\u540e\uff0c\u5e73\u5b89\u591c\u63a5\u6536\u3002<\/p>\n
\u5feb\u4e24\u5e74\u7684\uff0c\u65e0\u6bd4\u7ea0\u7ed3\u7684\u7a3f\u5b50\uff0c\u5148\u540e\u88ab4\u4e2a\u6742\u5fd7\u76f4\u63a5\u62d2\u6389\u3002\u5c4c\u4e1d\u9006\u88ad\u4e86?<\/p>\n
\u8001\u5b9e\u8bdd\uff0c\u8fd9\u6b21\u6295\u7a3f\u771f\u7684\u6ca1\u6709\u4fe1\u5fc3\uff0c\u53ea\u662f\u60f3\u6539\u4e00\u6539\u3002\u6539\u5b8c\u540e\uff0c\u7a81\u7136\u60f3\u5230\uff0c\u5e72\u8106\u6295\u4e00\u4e0b\u770b\u770b\uff0c\u56e0\u4e3a\u4ee5\u524d\u8fde\u5ba1\u7a3f\u610f\u89c1\u90fd\u6ca1\u6709\uff0c\u90fd\u4e0d\u77e5\u9053\u7a3f\u5b50\u5dee\u5728\u54ea\u91cc\uff0c\u8981\u600e\u4e48\u6539\u3002J<\/p>\n
pathology\u592a\u5feb\uff0c\u540e\u8005\u8ba9\u5927\u4fee\u3002<\/p>\n
\u5728\u8fd9\u4e2a\u7a3f\u5b50\u4e0a\uff0c\u5728\u5199\u4f5c\u7684\u7b56\u7565\u4e0a\u9669\u4e9b\u8ddf\u5c0f\u8001\u677f\u95f9\u7ffb\u4e86\u3002\u56e0\u4e3a\u8fd9\u4e2a\u6545\u4e8b\u7684\u5199\u4f5c\u975e\u5e38\u96be\uff0c\u5f88\u591a\u53d1\u73b0\u90fd\u662fto be<\/p>\n
expected\u3002\u600e\u4e48\u80fd\u5c06\u4e2d\u4eba\u4e4b\u8c8c\uff0c\u6253\u626e\u6210\u8303\u51b0\u51b0\uff0c\u6291\u6216\u662f\u5434\u83ab\u6101?<\/p>\n
\u5927\u5bb6\u53ef\u4ee5\u770b\u770b\u6458\u8981\uff0c\u5c31\u77e5\u9053\u6587\u7ae0\u7684\u5927\u81f4\u5185\u5bb9\u4e86\u3002\u600e\u4e48\u5199\u5462?\u4e89\u8bba\u7684\u7126\u70b9\u5728\u4e8e\uff1a<\/p>\n
\u5c0f\u8001\u677f\u89c9\u5f97\u5e94\u8be5\u8fd9\u6837\u5199\uff1a<\/p>\n
Epigenetic repression of B-cell specific genes reveals ID2 as tumor<\/p>\n
suppressor in Burkitt lymphoma.<\/p>\n
Short title: ID2 is atumor suppressor in Burkitt lymphoma.<\/p>\n
\u800c\u6211\u8ba4\u4e3a\uff1a\u4e00\u4e2a\u57fa\u56e0\u5728\u80bf\u7624\u4e2d\u6ca1\u6709\u7a81\u53d8\u3001\u7532\u57fa\u5316\u3001LOH\uff0c\u8868\u8fbe\u4e0d\u6bd4\u6b63\u5e38\u7ec6\u80de\u4f4e\uff0c\u51ed\u4ec0\u4e48\u8bf4\u5b83\u662f\u6291\u764c\u57fa\u56e0?\u96be\u9053\u5c31\u51ed\u5b83\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7cfb\u751f\u957f?\u4f46\u662f\u8bf4\u4e0d\u5b9a\u5b83\u8fd8\u53ef\u4ee5\u6291\u5236\u6b63\u5e38\u7ec6\u80de\u751f\u957f?<\/p>\n
\u6240\u4ee5\uff0c\u6211\u89c9\u5f97\u5e94\u8be5\u8fd9\u6837\u5199\uff1a<\/p>\n
Decitabine represses translocated MYC oncogene in Burkitt lymphoma.<\/p>\n
Runningt title: Decitabine represses MYC in Burkitt lymphoma.<\/p>\n
\u6458\u8981\uff1a<\/p>\n
Burkittlymphoma (BL) is caused by translocation of MYC to an immunoglobulin<\/p>\n
locus. Driven by the immunoglobulinenhancer elements, MYC is constitutively<\/p>\n
expressed. DNA demethylation of BLcell lines is known to repress B-cell<\/p>\n
phenotype, whereas the mechanisms and itsconsequences are to be elucidated. We<\/p>\n
found that decitabine(5-aza-2-deoxycytidine, 5-aza-dC) treatment led to<\/p>\n
down-regulation of MYCexpression and inhibition of proliferation, which was<\/p>\n
associated with therepression of immunoglobulin enhancer elements and aberrant<\/p>\n
expression of E2A and ID2. We showthat decitabine activates NF-kB, thereby<\/p>\n
upregulating ID2, a novel NF-kB targetgene, which partly expains the loss of B<\/p>\n
cell phenotype. We conclude that DNAmethylation patterning of BL cells sustains<\/p>\n
the constitutive expression of thetranslocated MYC oncogene bymaintainance of B<\/p>\n
cell phenotype; and interference with the epigenetic program by decitabine<\/p>\n
results notonly in alteration of the specific differentiation program but also<\/p>\n
compromisedoncogene expression. Given that oncogene expression in many B-cell<\/p>\n
non-Hodgkinlymphomas depends on the activity of immunoglobulin gene<\/p>\n
transcription, thisstrategy may serve as a novel therapeutic approach.<\/p>\n
\u6211\u60f3\u63a8\u9500\u7684\u4e00\u4e2a\u7406\u5ff5\u662f\uff0c\u80bf\u7624\u7ec6\u80de\u4e00\u822c\u8fd8\u662f\u90e8\u5206\u4fdd\u5b58\u5176\u8d77\u6e90\u7684\u6b63\u5e38\u7ec6\u80de\u7684\u8868\u578b\uff0c\u800cdecitabine\u548cID2\u7b49\u53ef\u4ee5\u6291\u5236B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684B\u6dcb\u5df4\u7ec6\u80de\u8868\u578b\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u6240\u4ee5\u80bf\u7624\u7684B\u6dcb\u5df4\u7ec6\u80de\u8868\u578b\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u751f\u5b58\u662f\u81f3\u5173\u91cd\u8981\u7684\uff0c\u5e72\u9884\u8fd9\u4e00\u70b9\u53ef\u4ee5\u6cbb\u7597\u80bf\u7624\u3002<\/p>\n
\u4e0d\u7ba1\u600e\u4e48\u6837\uff0c\u5f97\u5230\u4e86\u4fee\u56de\u7684\u673a\u4f1a\uff0c\u8bc1\u660e\u5ba1\u7a3f\u4e13\u5bb6\u53ef\u80fd\u8fd8\u662f\u89c9\u5f97\u8fd9\u4e00\u70b9\u6bd4\u8f83sexy\u3002<\/p>\n
\u540e\u6765\u4fee\u56de\u7684\u65f6\u5019\uff0c\u5c0f\u8001\u677f\u6709\u4e86\u5e72\u52b2\uff0c\u5168\u6743\u8d1f\u8d23\uff0c\u6700\u7ec8\u7248\u672c\u7684\u6458\u8981\u5e76\u4e0d\u662f\u8fd9\u6837\u5b50\u7684\uff0c\u4f46\u662f\u4e5f\u65e0\u6240\u8c13\u4e86\u3002<\/p>\n
\u65b0\u4e00\u7248\u7684IF\u4eca\u65e5\u53d1\u8868\uff0cJournal of Pathology\u6500\u4e0a\u4e866.253\u5206\u7684\u9ad8\u5cf0\u3002\u60f3\u5230\u4e86\u81ea\u5df1\u6587\u7ae0\u7684\u7ecf\u5386\uff0c\u771f\u662f\u611f\u6168\u4e07\u5343\uff0c\u6240\u4ee5\u6709\u6b64\u8d34\u3002<\/p>\n
\u6211\u89c9\u5f97\u8001\u677f\u4eec\uff0c\u7279\u522b\u662f\u56fd\u5916\u7684\u8001\u677f\u4eec\uff0c\u4e00\u822c\u6c34\u5e73\u8fd8\u662f\u975e\u5e38\u9ad8\u7684\uff0c\u4f46\u8001\u677f\u7684focus\u53ef\u80fd\u5f88\u591a\u3002\u6240\u4ee5\uff0c\u505a\u535a\u58eb\u6216\u535a\u58eb\u540e\u7684\u5144\u5f1f\u4eec\uff0c\u6211\u4eec\u81ea\u5df1\u7684\u8bfe\u9898\uff0c\u6211\u4eec\u81ea\u5df1\u7684\u5fc3\u8840\uff0c\u6709\u65f6\u5019\u8fd8\u662f\u81ea\u5df1\u6700\u4e86\u89e3\uff0c\u6700\u77e5\u9053\u5b83\u7684\u4f18\u7f3a\u70b9\u3002\u81ea\u5df1\u7684\u8bfe\u9898\uff0c\u53ea\u201c\u505a\u201d\u662f\u4e0d\u591f\u7684\uff0c\u8fd8\u8981\u201c\u7231\u201d\uff0c\u624d\u66f4\u6709\u53ef\u80fd\u6210\u529f\u3002<\/p>\n
\u518d\u7b80\u5355\u8c08\u8c08\u8fd9\u7bc7\u6587\u7ae0\u521b\u610f\u7684\u6765\u6e90\uff0c\u53ef\u80fd\u8fd9\u4e00\u70b9\u5bf9\u54b1\u4eec\u56fd\u5185\u7684\u5c4c\u4e1d\u610f\u4e49\u66f4\u5927\u3002\u6587\u7ae0\u4e3b\u8981\u53d1\u73b0\u4e86Decitabine\u53ef\u4ee5\u6291\u5236\u8f6c\u4f4d\u764c\u57fa\u56e0MYC\uff0c\u600e\u4e48\u53d1\u73b0\u7684?\u54b1\u6b63\u5927\u5149\u660e\u5730\u5077\u6765\u7684\u3001\u6361\u6765\u7684\uff0cLeukemia.<\/p>\n
2008 Histone acetylation and DNA demethylation of B cells result in a<\/p>\n
Hodgkin-like<\/p>\n
phenotype.\u6211\u5206\u6790\u4e86\u8fd9\u7bc7\u6587\u7ae0\u7684\u57fa\u56e0\u82af\u7247\u7684\u539f\u59cb\u6570\u636e\uff0c\u53d1\u73b0decitabine\u548cTSA\u5904\u7406\u540e\uff0c\u4e09\u4e2a\u7ec6\u80de\u7cfb\u4e2dMYC\u7684\u8868\u8fbe\u90fd\u662f\u5927\u5e45\u4e0b\u8c03\u7684\uff0c\u7136\u540e\u7ecf\u8fc73\u4e2a\u6708\u7684\u5b9e\u9a8c\uff0c\u53bb\u9a8c\u8bc1\uff0c\u627e\u4e0b\u8c03\u7684\u673a\u5236\uff0c\u5c0f\u8001\u677f\u8bf4\uff0c\u4f1a\u4e0d\u4f1a\u662f\u56e0\u4e3adecitabine\u4e0a\u8c03\u4e86ID2?(Decitabine\u4e0a\u8c03ID2\u8fd9\u4e2a\u53d1\u73b0\u662fLeukemia\u8fd9\u7bc7\u6587\u7ae0\u91cc\u9762\u6709\u7684)\u3002\u7136\u540e\u6709\u4e86\u8fd9\u7bc7\u6587\u7ae0\u3002\u5927\u5bb6\u770b\u770bLeukemia\u8fd9\u7bc7\u6587\u7ae0\uff0c\u5c31\u66f4\u80fd\u4e86\u89e3\u6211\u7684\u601d\u8def\u4e86\u3002\u4ed6\u8bf4decitabine\u53ef\u4ee5\u6291\u5236B\u7ec6\u80de\u8868\u578b\uff0c\u6211\u5c31\u66f4\u8fdb\u4e00\u6b65\uff0c\u8bf4\u8868\u578b\u6291\u5236\u7684\u610f\u4e49\u3002<\/p>\n
\u76ee\u524d\u51e0\u4e4e\u6240\u6709\u671f\u520a\u90fd\u4f1a\u5bf9\u6765\u7a3f\u8fdb\u884c\u8bba\u6587\u67e5\u91cd\uff0c\u636e\u4e86\u89e3\u82f1\u6587\u6295\u7a3f\u76ee\u524d\u670995%\u4ee5\u4e0a\u7684\u671f\u520a\u662f\u4f7f\u7528iThenticate\/CrossRef\u68c0\u6d4b\u6765\u7a3f\uff0c\u6295\u7a3f\u524d\u68c0\u6d4b\u8bf7\u8ba4\u51c6CrossRef\u4e2d\u6587\u7f51\u7ad9\uff1ahttp:\/\/www.crossref.com.cn\/<\/a>\uff0c\u5b89\u5168\u53ef\u9760\uff0c\u6295\u7a3f\u65e0\u5fe7\uff01<\/p>\n","protected":false},"excerpt":{"rendered":" \u88ab\u4e09\u5206\u7684\u6742\u5fd7\u79d2\u62d2\u5230\u53d1\u8868\u4e8e6\u5206\u591a\u7684\u6742\u5fd7–\u5199\u4f5c\u771f\u7684\u5f88\u91cd\u8981\uff1f\u8fd8\u662f\u8fd0\u6c14\uff1f \u6587\u7ae0\u88abLeukem […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[6,7,8,9,19],"_links":{"self":[{"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/posts\/448"}],"collection":[{"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/comments?post=448"}],"version-history":[{"count":2,"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/posts\/448\/revisions"}],"predecessor-version":[{"id":450,"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/posts\/448\/revisions\/450"}],"wp:attachment":[{"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/media?parent=448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/categories?post=448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.crossref.com.cn\/news\/wp-json\/wp\/v2\/tags?post=448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}